Stem Cell Center, Yale: Stem Cell Self-Renewal and Cell Symmetry
Our research efforts are focused primarily on elucidation of molecular mechanisms of skin cancer development. This occurs in two main areas. First, we are studying how normal keratinocytes and squamous cell skin cancers regulate the process of mRNA translation, facilitating the translation of certain mRNA into proteins while inhibiting others. This post-transcriptional control of gene expression plays a critical role in many aspects of biology, but has not been fully explored in the skin. We have identified a role for the Pumilio family of RNA binding proteins in regulating apoptosis, or cell death, within the epidermis, and we are also developing systems to identify novel regulators in the epidermal response to ultratiolet light. The second major area of research is focused on how mutations in critical tumor suppressor genes such as p53 allow mutated clones of cells to expand within defined fields of skin, eventually leading to cancer.
- Bazex syndrome (acrokeratosis paraneoplastica). Poligone B, Christensen SR, Lazova R, Heald PW. Lancet. 2007 Feb 10;369(9560):530.
Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach.
Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Journal of the American Academy of Dermatology, 2016 Feb;74(2):356-62.
- Sirolimus-associated rapid progression of leg ulcers in a renal transplant recipient Totonchy, MB, Colegio, OR, Christensen, SR. JAMA Dermatology, 2016; 153:105-106.