The Xiao Lab focuses on characterizing unique cellular and molecular features of pluripotent stem cells (PSCs) and the underlying epigenetic mechanisms (Dan et al., Developmental cell 29, 7-19, 2014; Wu et al. Cell stem cell 15, 281-294, 2014). We are credited with the recent discovery of a novel DNA modification, N6-methyladeine, in mammals (Nature 532, 329-333, 2016). Our ongoing research encompasses three areas: (1) novel DNA modifications in mammals, their modification machineries and effector binding proteins; (2) novel chromatin/histone mechanisms underlying preimplantation embryo development and cellular reprogramming; and (3) the functions of these novel epigenetic mechanisms in early embryogenesis and adult tissue stemcells, and in human diseases.
- Well-trained in biochemistry and molecular biology, cell and developmental biology or genomics, epigenetics and bioinformatics/computational biology as demonstrated by a solid publication record.
- Abilities to lead an independent research direction while adapting to a collaborative and challenging research environment.
- Ability to develop experimental and computation approaches and acquire new concepts and research skills quickly.
- An innovative yet critical thinker.
Candidates with following research experiences are highly encouraged to apply:
- Pre-implantation embryos (Zygotic to blastocyst stage) and cellular reprogramming
- Germ cells
- Neural development
- Immunology and infection diseases
- Human and primate ESC and/or iPSCs
- Genomics and bioinformatics
- Epigenetics, including small RNAs and chromatin biology and chromatin biology
- Nuclear cell biology and super-resolution imaging