Multiple Postdoctoral Associate Positions Available at the Xiao Lab

The Xiao Lab focuses on characterizing unique cellular and molecular features of pluripotent stem cells (PSCs) and the underlying epigenetic mechanisms (Dan et al., Developmental cell 29, 7-19, 2014; Wu et al. Cell stem cell 15, 281-294, 2014). We are credited with the recent discovery of a novel DNA modification, N6-methyladeine, in mammals (Nature 532, 329-333, 2016).  Our ongoing research encompasses three areas:  (1) novel DNA modifications in mammals, their modification machineries and effector binding proteins; (2) novel chromatin/histone mechanisms underlying preimplantation embryo development and cellular reprogramming; and (3) the functions of these novel epigenetic mechanisms in early embryogenesis and adult tissue stemcells, and in human diseases.

General requirements:

  • Well-trained in biochemistry and molecular biology, cell and developmental biology or genomics, epigenetics and bioinformatics/computational biology as demonstrated by a solid publication record. 
  • Abilities to lead an independent research direction while adapting to a collaborative and challenging research environment. 
  • Ability to develop experimental and computation approaches and acquire new concepts and research skills quickly.
  • An innovative yet critical thinker.


Candidates with following research experiences are highly encouraged to apply:

  • Pre-implantation embryos (Zygotic to blastocyst stage) and cellular reprogramming
  • Germ cells
  • Neural development
  • Tumorigenesis
  • Immunology and infection diseases
  • Human and primate ESC and/or iPSCs
  • Genomics and bioinformatics
  • Epigenetics, including small RNAs and chromatin biology and chromatin biology 
  • Nuclear cell biology and super-resolution imaging

        Contact:   Andrew.Xiao@yale.edu