Position in the laboratory of Dr. Andrew Xiao

Post-doctoral positions are available in the laboratory of Andrew Xiao , Ph.D., Yale Stem Cell Center, Department of Genetics, Yale University School of Medicine, New Haven, CT. With an emphasis on histone variants, modifications and chromatin remodeling complexes, the lab focuses on investigating molecular mechanisms for mammalian stem cell biology (toti- and pluri-potent), cellular reprogramming (iPS) and embryonic development.

Our research has revealed several new functions of histone variant H2A.X and its novel kinase WSTF in maintaining genome integrity (Nature(2009) V457, 57-62 ). Our latest findings motivate us to investigate how H2A.X and WSTF coordinate genome integrity and gene expression in stem cell and during reprogramming (iPS).Since WSTF is frequently deleted in human Williams Syndrome, we are investigating its role during development.We have multiple well-funded projects available using biochemistry, cell biology, mouse genetics, and genomics & bioinformatics (Chip-Seq and RNA-Seq) tools to study these questions.

Yale Stem Cell Center and Department of Genetics provide a stimulating and collaborative training environment, as well as cutting edge facilities.We are enjoying collaborations with many world-renownfaculty members at Yale.

Essential Qualifications: A successful candidate should be self-motivated with a strong background and experimental skills in molecular biology, as well as a track record of publication. Previous experiences in afore-mentioned fields are welcome but not required.Interested applicants should send CV and contact information of three references to:

Andrew Xiao , Ph.D.

Yale Stem Cell Center, Yale University School of Medicine

P.O. Box 208073

New Haven, CT 06520-8073

xiaoa@rockefeller.edu